易制爆危险化学品
Sodium borohydride
硼氢化钠

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  • Mol. Formula: NaBH4
  • Mol. Weight: 37.83
  • Melting Point: >;300 °C (dec.)(lit.)
  • Density: 0.998 g/mL at 25 °C
  • TSCA: Yes
  • Solubility: Soluble in water, ammoni...
  • Boiling Point: 130°C
  • Flash Point: 69 ºC
  • Stability: 对湿度敏感
  • Appearance: {Chemicalbook} {Chemic...
Chemical NameSodium borohydride
Synonym
  • VenPure® 四氢硼酸钠
  • Natriumborhydrid
  • 四氢硼酸(1-)钠
  • Sodium tetrahydroborate
  • sodiumborohydrate
  • Sodium tetrahydridoborate
  • Natriumtetrahydridoborat
  • Sodium borohydrate
  • 硼氢钠
  • COBALT-DOPED SODIUM BOROHYDRIDE
  • SODIUM TETRAHYDROBORATE
  • Sodium borohydride
  • 硼氢化钠, 98% MIN
  • VenPure® AF 四氢硼酸钠
  • BH4Na
  • AF
  • 硼氢化钠, 97+%
  • hidkitexdf
  • Natriumborhydrid auf aluminiumoxid
  • Borate(1-), tetrahydro-, sodium
  • borohydruredesodium(french)
  • Sodium hydroborate
  • BH4Na
  • 四氢硼酸钠 钴掺杂的硼氢化钠
  • Borohydrure de sodium
  • 四氢硼酸钠 硼氢化钠
  • 氧化铝负载硼氢化钠
  • SBH
  • 四氢硼酸钠
  • Borol
  • SODIUM TETRAHYDRIDOBORATE
  • 四氢硼钠
  • Sodium borohydride (Na(BH4))
  • NaBH4
  • Natriumborhydrid (Feingranulat)
  • Sodium borohydride (NaBH4)
  • NaBH4
  • borol
  • SODIUM BOROHYDRIDE
  • SODIUM BORANATE
  • 硼氢化钠
  • 四氢硼化钠
  • SODIUM TETRAHYDRIDEBORATE
  • Sodium tetrahydroborate(1-)
  • Borate(1-)tetrahydro-,sodium
  • Natriumboranat
  • borohydruredesodium
  • Borate(1-),tetrahydro-,sodium
  • 硼氢钠,四氢硼钠,钠硼氢,氢硼化钠,四氢硼酸钠
  • 硼氢化钠, STABLE AQ. SOLN., 4.4M IN 14M NAOH
  • Hidkitex DF
  • 硼氢化钠 溶液
  • 氢硼化钠
CAS Number16940-66-2
PubChem Substance ID 24868735
EC Number241-004-4
MDL NumberMFCD00003518
Merck Number14,8592
Beilstein Registry Number2384789
Chemical Name Translation硼氢化钠
Wiswesser Line NotationNA B-H4
GHS Symbol
WGK Germany2
Hazard Codes
  • 4.3
  • F,T
  • F,C
  • F,T,N
  • F,T,N,C,Xn
  • T
  • C
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H260 In contact with water releases flammable gases which may ignite spontaneously 与水接触时释放可燃气体,可自燃。
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H261 In contact with water releases flammable gas 与水接触时释放可燃气体。
  • H301+311
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H350 May cause cancer 可能致癌
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Personal Protective Equipment
  • Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
  • dust mask type N95 (US), Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges
  • Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
  • Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges
RTECSED3325000
Precautionary statements
  • P402+404 Store in a dry place. Store in a closed container. 存放在干燥的地方。贮存于密闭容器中。
  • P308+313 IF exposed or concerned: Get medical advice/attention. 如接触到或有疑虑:求医/就诊。
  • P231+232 Handle under inert gas. Protect from moisture. 在惰性气体中。防止受潮。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P370+378 In case of fire: Use … for extinction. 如果发生火灾:使用...灭火。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P261305+351+338
  • P304+340+310
  • P305+351+338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. 如接触到眼睛:小心地用水冲洗几分钟。如果佩戴隐形眼镜并容易取出的话,取出隐形眼镜。继续冲洗。
  • P301+312+330
  • P303+361+353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. 如果沾上皮肤(或头发):删除/立即脱掉所有被污染的衣服。清洗/淋浴冲洗皮肤。
  • P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire. 远离任何与水接触的可能,因为会剧烈反应可能产生闪火。
  • P422 Store contents under… 存储目录在…之下。
  • P223231+232280301+310370+378422
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P301+310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. 如果食入:立即呼叫中毒控制中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Signal word
  • Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S7/8 Keep container tightly closed and dry 保存在严格密闭容器中,保持干燥;
  • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
  • S35 This material and its container must be disposed of in a safe way 该物料及其容器必须以安全方式处置;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S22 Do not breathe dust 不要吸入粉尘;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S4 Keep away from living quarters 远离生活区;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
  • S50 Do not mix with ... (to be specified by the manufacturer) 不要与……(由生产厂家指定)混合;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
UN Number
  • UN1426
  • UN 3129 4.3/PG 3
  • UN3320
Risk Statements
  • R19 May form explosive peroxides 可能生成易爆的过氧化物质
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R15 Contact with water liberates extremely flammable gases 遇水会释放出极端易燃的气体
  • R34 Causes burns 会导致灼伤
  • R60 May impair fertility 可能降低生殖能力
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R42/43
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R51/53
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R35 Causes severe burns 会导致严重灼伤
  • R49 May cause cancer by inhalation 吸入会致癌
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R50/53
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition
  • Moisture Sensitive
  • Store at RT.
  • 密封阴凉干燥保存
  • 充氩保存
  • Air Sensitive
Packing GroupII
Hazard Class4.3
Restrict
  • 易制爆危险化学品
Warnings
  • 危化品目录(2015)
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 17,124,1958
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
  • 硼氢化钠是一种良好的还原剂,它的特点是性能稳定,还原时有选择性。可用作醛类、酮类和酰氯类的还原剂,塑料的发泡剂,制造双氢链霉素的氢化剂,制硼氢化钾的中间体,合成硼烷的原料,以及用于造纸工业含汞污水的处理剂。用作制造乙硼烷和其他高能燃料的原料,也用于医药工业等。
  • Acid chlorides are readily reduced to alcohols; controlled reduction at -78o to give the aldehyde has been reported; see, e.g.: Synth. Commun., 12, 839 (1982). See also Bis(triphenyl­phosphine)­copper(I)­ borohydride, A13730. For an indirect method of reduction, see Triethyl­ phosphite, L00339.
  • For a brief feature on uses of the reagent in synthesis, see: Synlett, 182 (
  • LiCl: reduction of amino acids via Me esters: Tetrahedron Lett., 39, 917 (1998). CaCl2: selective 1,2-reduction enones: Chem. Lett., 1847 (1991). CeCl3: increased selectivity for 1,2-reduction of enones: J. Chem. Soc., Chem. Commun., 601 (1978); reduction of ketones in the presence of aldehydes: J. Am. Chem. Soc., 101, 5848 (1979). CuCl: dehalogenation of aryl iodides and bromides: J. Org. Chem., 54, 5308 (1989); reduction of nitro compounds: Chem. Ind. (London), 75 (1984). CuSO4: reduction of esters, alkenes, nitriles and nitro compounds; amides and acids inert: Synlett, 419 (1990) [but see also Synlett, 79 (1993): Cu(OAc)2 preferred for reduction of nitro-groups]; reduction of azides: Synth. Commun., 24, 549 (1994). NiCl2: generation in situ of nickel boride, as an alternativ
  • Merck: 14,8592
  • Reductive alkylation of amines can be effected with NaBH4/formaldehyde; see e.g.: Synthesis, 743 (1980); or TFA: Synthesis, 709 (1987). See also Sodium cyanoborohydride, 87839. Reductive alkylation of aromatic amines with a variety of aldehydes and ketones has been reported, using NaBH4/H2SO4: Synthesis, 121 (1993).
  • The reduction of aldehydes and ketones to alcohols occurs in alcoholic or aqueous media. For highly selective reduction of aldehydes in the presence of ketones, see: Synth. Commun., 18, 1927 (1988). For enantioselective reduction, see L-tert-Leucine, L13707. Borohydride reductions can be carried out in organic solvents, e.g. toluene, under phase-transfer conditions, amenable to scale-up: Org. Process Res. Dev., 1, 287 (1997).
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