易制毒化学品
Chloroform
三氯甲烷

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  • Mol. Formula: CHCl3
  • Mol. Weight: 119.38
  • Refractive index: n20/D 1.445(lit.)
  • Boiling Point: 60.5-61.5 °C(lit.)
  • Density: 1.492 g/mL at 25 °C(lit....
  • Melting Point: -63 °C(lit.)
  • TSCA: Yes
  • Vapor Density: 4.1 (vs air)
  • Vapor Pressure: 160 mmHg ( 20 °C)
  • Solubility: 8 G/L (20 ºC)
  • Flash Point: 60.5-61.5°C
  • Stability: 对光敏感
Chemical NameChloroform
Synonym
  • Trichloromethane
  • CHLOROFORM
  • 氯仿, SPECTROPHOTOMETRIC GRADE, 99.5+%
  • 三氯甲烷( 易制毒化学品,禁止定购)
  • Trichlormethan
  • 氯仿
  • Triclorometano
  • 三氯甲烷
  • METHYLIDYNE TRICHLORIDE
  • Formyl trichloride
  • HCC20
  • Methane,trichloro-
  • RCRA waste number U044
  • 氯仿,三氯甲烷,哥罗念头
  • 氯仿溶液
  • freon20
  • 氯仿 99.5% (GC)
  • Freon 20
  • 哥罗仿,氯仿
  • TRICHLOROMETHANE
  • 氯仿;氯仿溶液
  • Cloroformio
  • AKOS BBS-00004224
  • 氯仿, 不含乙醇, 99+%, .含大约 50PPM戊烯作稳定剂
  • Trichloroform
  • SOLVENT MC
  • Methylidyne trichloride 三氯甲烷
  • formyltrichloride
  • 哥罗仿;氯仿
  • Methane, trichloro-
  • Methane trichloride
  • 氯仿, HPLC GRADE, 99.5+% MIN, 戊烯作稳定剂
  • chloroform(trichloromethane)
  • 三氯甲烷 054-01 [6]
  • CHCl3
  • 氯仿, ENVIRONMENTAL GRADE, 99.8+%, 乙醇作稳定剂
  • chloroforme(french)
  • R 20
  • CHLOROFORM 5000
  • 氯仿, 99%, 以大约 1%乙醇作稳定剂
  • R 20 (Refrigerant)
  • 氯仿, ACS, 99.8+%
  • NCI-C02686
  • Trichloormethaan
  • Methyl trichloride
  • 氯仿, HPLC GRADE, 99.5+% MIN
  • 哥罗仿
  • Chloroform
  • Chloroforme
  • Methenyl trichloride
  • 氯仿 溶液
CAS Number67-66-3
PubChem Substance ID 24871551
EC Number200-663-8
Beilstein Registry Number1731042
MDL NumberMFCD00000826
Merck Number14,2141
Chemical Name Translation三氯甲烷
Wiswesser Line NotationGYGG
GHS Symbol
WGK Germany3
Hazard Codes
  • Xn
  • F,Xn
  • F,Xi
  • Xn,F,T
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H331 Toxic if inhaled 吸入中毒
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H302 Harmful if swallowed 吞食有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment
  • Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
RTECSFS9100000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+340+312
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P370+378 In case of fire: Use … for extinction. 如果发生火灾:使用...灭火。
  • P403+235 Store in a well-ventilated place. Keep cool. 存放在通风良好的地方。保持凉爽。
  • P305+351+338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. 如接触到眼睛:小心地用水冲洗几分钟。如果佩戴隐形眼镜并容易取出的话,取出隐形眼镜。继续冲洗。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P403+233 Store in a well-ventilated place. Keep container tightly closed. 存放在通风良好的地方。保持容器密闭。
  • P308+313 IF exposed or concerned: Get medical advice/attention. 如接触到或有疑虑:求医/就诊。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Signal word
  • Danger
UN Number
  • UN 1888 6.1/PG 3
Risk Statements
  • R11 Highly flammable 非常易燃
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R48/20/22
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R36 Irritating to eyes 刺激眼睛
  • R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
  • R20 Harmful by inhalation 吸入有害
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R45 May cause cancer 可能致癌
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
  • R38 Irritating to skin 刺激皮肤
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S25 Avoid contact with eyes 避免眼睛接触;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Packing GroupⅢ
Hazard Class6.1
Storage condition
  • 储存温度2-8℃
  • 2-8°C
  • 密封避光阴凉处保存。
Restrict
  • 易制毒化学品
Warnings
  • 危化品目录(2015)
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 98 gm/kg/78W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Endocrine - thyroid tumors REFERENCE : NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-0,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13832 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,760,1985
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 70 gm/kg/78W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Endocrine - thyroid tumors REFERENCE : NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-0,1976
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TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 58968 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Blood - tumors REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,760,
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED
TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 6 gm/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 97,86,1923
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 10 mg/m3/1Y TOXIC EFFECTS : Behavioral - anorexia (human) Gastrointestinal - nausea or vomiting Gastrointestinal - other changes REFERENCE : IRGGAJ Internationales Archiv fuer Gewerbepathologie und Gewerbehygiene. (Heidelberg, Fed. Rep. Ger.) V.19-25, 1962-69. For publisher information, see IAEHDW. Volume(issue)/page/year: 24,127,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 704 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,224,1958
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 47702 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ENVRAL Environmental
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - hamster Fibroblast DOSE/DURATION : 1 pph REFERENCE : ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 43,21,1975
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 10 mmol/L REFERENCE : ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/p
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TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 200 mg/kg/4D (Intermittent) REFERENCE : ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 32,72,1983
TYPE OF TEST : Mutation test systems - not otherw
TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Inhalation TEST SYSTEM : Rodent - mouse DOSE/DURATION : 300 ppm/6H REFERENCE : IGAYAY Igaku No Ayumi. Progress in Medicine. (Ishiyaku Shuppan K.K., 1-7-10, Honkomagom, Bunkyo-ku, Tokyo, Japan) V.1- 1946- Volume(issue)/page/year: 122,978,1982
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human HeLa cell DOSE/DURATION : 19 mmol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham,
TYPE OF TEST : DNA adduct TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 1 mmol/L REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1
TYPE OF TEST : TDL
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE : 30 ppm/7H SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,442,1974
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE : 20100 ug/m3/1H SEX/DURATION : female 7-14 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB277-077
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 4 gm/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976- Volume(issue)/page/year: 18,333,1983
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  • Merck: 14,2141 Beilstein: 1,IV,42
  • For example of use in the generation of dichlorocarbene under phase-transfer catalysis, see: Org. Synth. Coll., 7, 12 (1990). See also Bromoform, A11904.
  • Merck: 14,2141
  • In the presence of base, phenols undergo formylation predominantly in the ortho-position, to give salicylaldehyde derivatives (the Reimer-Tiemann reaction). The mechanism probably involves dichlorocarbene, and yields are generally rather low. For an example, see: Org. Synth. Coll., 3, 463 (1955); review: Org. React., 28, (1982). Improved procedures have been reported: Synth. Commun., 18, 2095 (1988); and, using ultrasound: Synth. Commun., 20, 609 (1990); for an example, see 4-Chlorophenol, A15602.
  • For example of use in the generation of dichlorocarbene under phase-transfer catalysis, see: Org. Synth. Coll., 7, 12 (1990). See also Bromoform, A11904.
  • In the presence of base, phenols undergo formylation predominantly in the ortho-position, to give salicylaldehyde derivatives (the Reimer-Tiemann reaction). The mechanism probably involves dichlorocarbene, and yields are generally rather low. For an example, see: Org. Synth. Coll., 3, 463 (1955); review: Org. React., 28, (1982). Improved procedures have been reported: Synth. Commun., 18, 2095 (1988); and, using ultrasound: Synth. Commun., 20, 609 (1990); for an example, see 4-Chlorophenol, A15602.
  • 部分产品数据参考 LabNovo , 请谨慎使用并以实际实验测量值为准。